In 2020, over 11 million Indigenous people resided in the United States and its territories. Colonization’s historical impacts, including war, slavery, boarding schools, land theft, diseases, and racism, have caused lasting traumas. Today, colonization persists through land and water management practices that prioritize economic interests, harming Indigenous lands and food security. Non-Indigenous land management contributes to species and ecosystem decline, threatening Indigenous well-being and limiting subsistence and food security. ChildTrends’s article explores 5 ways that subsistence practices support Indigenous child and family well-being. Indigenous Peoples cherish subsistence as a sacred, holistic way of life, embracing spirituality, ancestral connections, and environmental stewardship for their overall well-being.